Interdisciplinary Glycoimmunology

Using Chemical Approaches To Study How Glycans Influence Our Immune Cells.
Welcome to the Macauley Lab
Macauley Lab 2023

Siglec-glycan Interactions

Our lab uses advanced chemical and biochemical approaches to study Siglecs with the primary motivating question being:

What are the glycans recognized by Siglecs?
Examples of Siglecs recognizing a glycan ligand on the same cell (left) or on another cell (right) to modulate the response of the white blood cell.
Tackling challenging questions in immunology with chemistry by:
  • Creating Multivalent, genetically encoded Siglec probes
  • Discovering foundational biological roles for Siglecs and their glycan ligands
  • Manipulating cellular glycans with chemical probes
The Macauley Lab

Department of Chemistry
University of Alberta

Through interdisciplinary research, the Macauley Lab aims to better understand how glycans modulate our immune cells and develop small molecule tools and inhibitors.

The ability of our immune system to actively recognize our own cells and tissues are critical because mechanisms that maintain immune homeostasis continue to be incompletely understood.

Join Our Lab

Please contact Dr. Macauley if interested in our laboratory.
We encourage diverse applicants to apply. Please provide a copy of your CV.

Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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