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Publication – Dissecting the abilities of murine Siglecs to interact with gangliosides

Excited to share the work that Eddie has recently published in The Journal of Biological Chemistry. Dissecting the abilities of murine Siglecs to interact with gangliosides,Journal of Biological Chemistry,Edward N. Schmidt, Xue Yan Guo, Duong T. Bui, Jaesoo Jung, John S. Klassen, Matthew S. Macauley,2024, 107482, ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2024.107482. Read the full article here. Siglecs […]

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Publication – Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Excited to share our finished product on dissecting roles for CD33 isoforms in a mouse model of amyloidosis in Molecular Neurodegeneration. Ghaz got tremendous help from a talented undergrad Madeline Crichton. Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice.  Eskandari-Sedighi, G., Crichton, M., Zia, S. et al. Mol Neurodegeneration19, 42

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Publication – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors

Excited to share Kelli’s major PhD work that was published in ACS Central Science – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors Kelli A. McCord, Chao Wang, Mirjam Anhalt, Wayne W. Poon, Amanda L. Gavin, Peng Wu, and Matthew S. Macauley. ACS Central Science Article ASAPDOI: 10.1021/acscentsci.3c00969 Abstract Fcγ receptors (FcγRs) play key roles

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Publication – Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing

Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing. Santiago Tijaro-Bulla, Eiman A. Osman, Chris D. St Laurent, Kelli A. McCord, Matthew S. Macauley, and Julianne M. Gibbs. ACS Chemical Biology 2023 18 (10), 2156-2162DOI: 10.1021/acschembio.3c00140 Abstract CRISPR-Cas9 is currently the most versatile technique to perform gene editing in living organisms. In this

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Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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