Folio – New research reveals clues to how antibodies get fine-tuned to fight infection

New research reveals clues to how antibodies get fine-tuned to fight infection

U of A Folio Press Release

Scientists discover a cellular mechanism that may yield insights into improving vaccines and better understanding cancer and autoimmune diseases.
MARCH 15, 2022 BY ADRIANNA MACPHERSON

Abstract

The antibodies our immune system produces need fine-tuning to reach maximum effectiveness. When a vaccine or pathogen is first introduced into our bodies, antibodies produced against these agents help protect us — but need to be optimized, explained Matthew Macauley, assistant professor in the Department of Chemistry.

“Slowly, our immune system improves the ability of the antibody to recognize their target, and makes them better and better.”

Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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