Folio – U of A chemists discover how a plaque-fighting protein protects against Alzheimer’s

U of A chemists discover how a plaque-fighting protein protects against Alzheimer’s

Press Release

Research highlights potential pathway for new treatments for neurodegenerative diseases.
APRIL 07, 2021 BY KATIE WILLIS

Abstract

There are two versions, or isoforms, of the CD33 protein: a long version that increases susceptibility to Alzheimer’s disease and a short version that decreases the chance of getting the debilitating neurodegenerative disease. 

“We found that the short isoform has a completely different and opposite function from the long isoform,” explained Matthew Macauley, assistant professor in the Department of Chemistry and Canada Research Chair in Chemical Glycoimmunology. 

Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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