Melissa Macauley

Publication – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors

Excited to share Kelli’s major PhD work that was published in ACS Central Science – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors Kelli A. McCord, Chao Wang, Mirjam Anhalt, Wayne W. Poon, Amanda L. Gavin, Peng Wu, and Matthew S. Macauley. ACS Central Science Article ASAPDOI: 10.1021/acscentsci.3c00969 Abstract Fcγ receptors (FcγRs) play key roles

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The Carbohydrate Connection: Finding a Way to Target Alzheimer’s

“About 10% of people make more of this shorter form and they have less of a chance of getting Alzheimer’s disease,” said Dr. Macauley. The research team is working to understand why that’s the case, with the goal of leveraging that knowledge towards developing a therapeutic treatment for Alzheimer’s disease.  “The fundamental nature of our

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Alzheimer’s – Hope for Tomorrow

Hope for Tomorrow Research Competition Launched in September of 2022, the Hope for Tomorrow Research Competition supports top neuroscience researchers in high priority areas concerning Alzheimer’s and dementia. This first iteration ran under the theme “Quality of Life”, supporting projects with potential to have a significant impact on the lives of people with Alzheimer’s and dementia in

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Publication – Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing

Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing. Santiago Tijaro-Bulla, Eiman A. Osman, Chris D. St Laurent, Kelli A. McCord, Matthew S. Macauley, and Julianne M. Gibbs. ACS Chemical Biology 2023 18 (10), 2156-2162DOI: 10.1021/acschembio.3c00140 Abstract CRISPR-Cas9 is currently the most versatile technique to perform gene editing in living organisms. In this

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Folio – New research reveals clues to how antibodies get fine-tuned to fight infection

Abstract The antibodies our immune system produces need fine-tuning to reach maximum effectiveness. When a vaccine or pathogen is first introduced into our bodies, antibodies produced against these agents help protect us — but need to be optimized, explained Matthew Macauley, assistant professor in the Department of Chemistry. “Slowly, our immune system improves the ability of the

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Making strides in Alzheimer’s research

Abstract “One striking observation made in the last 5–10 years is that genetic factors that can influence your susceptibility to Alzheimer’s disease converge on immune cells in the brain, called microglia,” says Matthew Macauley, GlycoNet researcher and Canada Research Chair in Chemical Glycoimmunology at the University of Alberta (U of A). In Alzheimer’s disease, neurodegenerative plaques begin forming

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Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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