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The Carbohydrate Connection: Finding a Way to Target Alzheimer’s

“About 10% of people make more of this shorter form and they have less of a chance of getting Alzheimer’s disease,” said Dr. Macauley. The research team is working to understand why that’s the case, with the goal of leveraging that knowledge towards developing a therapeutic treatment for Alzheimer’s disease.  “The fundamental nature of our

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Alzheimer’s – Hope for Tomorrow

Hope for Tomorrow Research Competition Launched in September of 2022, the Hope for Tomorrow Research Competition supports top neuroscience researchers in high priority areas concerning Alzheimer’s and dementia. This first iteration ran under the theme “Quality of Life”, supporting projects with potential to have a significant impact on the lives of people with Alzheimer’s and dementia in

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Folio – New research reveals clues to how antibodies get fine-tuned to fight infection

Abstract The antibodies our immune system produces need fine-tuning to reach maximum effectiveness. When a vaccine or pathogen is first introduced into our bodies, antibodies produced against these agents help protect us — but need to be optimized, explained Matthew Macauley, assistant professor in the Department of Chemistry. “Slowly, our immune system improves the ability of the

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Making strides in Alzheimer’s research

Abstract “One striking observation made in the last 5–10 years is that genetic factors that can influence your susceptibility to Alzheimer’s disease converge on immune cells in the brain, called microglia,” says Matthew Macauley, GlycoNet researcher and Canada Research Chair in Chemical Glycoimmunology at the University of Alberta (U of A). In Alzheimer’s disease, neurodegenerative plaques begin forming

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Folio – SARS-CoV-2 uses sugars to invade human cells, new study shows

Abstract Sugars found on the surface of human cells influence COVID-19 infection, according to a University of Alberta-led study that is one of the first to observe this relationship and suggests that cells in the brain might be particularly susceptible. “The idea here is that the virus is leveraging or using the host glycans, or the host

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Folio – U of A chemists discover how a plaque-fighting protein protects against Alzheimer’s

Abstract There are two versions, or isoforms, of the CD33 protein: a long version that increases susceptibility to Alzheimer’s disease and a short version that decreases the chance of getting the debilitating neurodegenerative disease.  “We found that the short isoform has a completely different and opposite function from the long isoform,” explained Matthew Macauley, assistant professor

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Folio – Scientists develop new tools to study the immune system

Abstract “Our lab studies sugar-binding receptors called Siglecs that control cells in our immune system,” explained Matthew Macauley, assistant professor in the Faculty of Science and Canada Research Chair in Chemical Glycoimmunology. “Studying the sugar-binding properties of Siglecs is challenging because these biochemical interactions are weaker than typical protein-protein interactions.” To address this, the research team used a

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Folio – How a protein in your brain could protect against Alzheimer’s disease

Abstract New research has found that the most common version of a protein called CD33 plays a crucial role in regulating white blood cells in the human brain, which could have important implications in the fight against Alzheimer’s disease. The study builds on previous research that had identified the protein as a factor that may

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Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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