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Publication

Publication – Dissecting the abilities of murine Siglecs to interact with gangliosides

Excited to share the work that Eddie has recently published in The Journal of Biological Chemistry. Dissecting the abilities of murine Siglecs to interact with ...
Publication

Publication – Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

Excited to share our finished product on dissecting roles for CD33 isoforms in a mouse model of amyloidosis in Molecular Neurodegeneration. Ghaz got tremendous help ...
Press Release

Alzheimer’s Society Lab Tour

Check out the lab tour from the Alberta Alzheimer Society.
Lab News

Lab News – Dr. Jhon enterina

Big congrats to Dr. Jhon Enterina on a successful PhD defense. It was an honor to introduce him for his talk. Special thanks to Bebhinn ...
Publication

Publication – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors

Excited to share Kelli’s major PhD work that was published in ACS Central Science – Dissecting the Ability of Siglecs To Antagonize Fcγ Receptors Kelli ...
Press Release

The Carbohydrate Connection: Finding a Way to Target Alzheimer’s

“About 10% of people make more of this shorter form and they have less of a chance of getting Alzheimer’s disease,” said Dr. Macauley. The ...
Lab News

Lab News – Graduation and Successful Defense

Big week for the lab with the first PhD graduation, Jaesoo, and 2nd successful defense, Kelli McCord). Both are headed to America for postdocs. Congrats ...
Press Release

Alzheimer’s – Hope for Tomorrow

Hope for Tomorrow Research Competition Launched in September of 2022, the Hope for Tomorrow Research Competition supports top neuroscience researchers in high priority areas concerning Alzheimer’s and ...
Publication

Publication – Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing

Disrupting Protein Expression with Double-Clicked sgRNA–Cas9 Complexes: A Modular Approach to CRISPR Gene Editing. Santiago Tijaro-Bulla, Eiman A. Osman, Chris D. St Laurent, Kelli A. ...
Awards and Grants

Jhon Enterina is awarded prestigious Izaak Walton Killam Memorial Scholarship

A love and curiosity for biology started Enterina’s journey toward working with B cells — research with important implications in the area of vaccine development, ...
Press Release

Folio – New research reveals clues to how antibodies get fine-tuned to fight infection

Abstract The antibodies our immune system produces need fine-tuning to reach maximum effectiveness. When a vaccine or pathogen is first introduced into our bodies, antibodies ...
Press Release

Making strides in Alzheimer’s research

Abstract “One striking observation made in the last 5–10 years is that genetic factors that can influence your susceptibility to Alzheimer’s disease converge on immune ...
Awards and Grants

Dr. Macauley Awarded the Raymond U. Lemieux Chair in Carbohydrate Chemistry

Press Release

Folio – SARS-CoV-2 uses sugars to invade human cells, new study shows

Abstract Sugars found on the surface of human cells influence COVID-19 infection, according to a University of Alberta-led study that is one of the first to observe ...
Press Release

Folio – U of A chemists discover how a plaque-fighting protein protects against Alzheimer’s

Abstract There are two versions, or isoforms, of the CD33 protein: a long version that increases susceptibility to Alzheimer’s disease and a short version that ...
Press Release

Folio – Scientists develop new tools to study the immune system

Abstract “Our lab studies sugar-binding receptors called Siglecs that control cells in our immune system,” explained Matthew Macauley, assistant professor in the Faculty of Science and Canada Research ...
Press Release

Folio – How a protein in your brain could protect against Alzheimer’s disease

Abstract New research has found that the most common version of a protein called CD33 plays a crucial role in regulating white blood cells in ...
Press Release

Press Release – Funding research toward the prevention of Alzheimer’s disease

Abstract “If we could understand why that DNA sequence protects someone from getting Alzheimer’s disease, we could then leverage that to try to develop a ...
Awards and Grants

Press Release – Funding research toward the prevention of Alzheimer’s disease

Abstract As Canadian Alzheimer’s Awareness Month wraps up, we shed some light on the work of Matthew Macauley, assistant professor in the Department of Chemistry and investigator with GlycoNet. ...
Press Release

Folio – New research approach could unlock some mysteries about Alzheimer’s

Abstract A new research project using a unique approach may help unlock clues as to how Alzheimer’s arises and point to potential targets for developing ...

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Territorial Acknowledgement

The University of Alberta, its buildings, labs, and research stations are primarily located on the traditional territory of Cree, Blackfoot, Métis, Nakota Sioux, Iroquois, Dene, and Ojibway/Saulteaux/Anishinaabe nations; lands that are now known as part of Treaties 6, 7, and 8 and homeland of the Métis. The University of Alberta respects the sovereignty, lands, histories, languages, knowledge systems, and cultures of First Nations, Métis and Inuit nations.

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